I have just completed the upgrade of my Grommunio server running on Leap 15.6. I run the 'base' product plus 'files' on this server. All went well with my test upgrade yesterday, but this was a test machiine/upgrade to test the process but I didn't check mail flow.
Today after completing the upgrade on my 'live' server (actually a copy VM of it) all went well with the update as per yesterdays test. However, when I re-enabled postfix I had no mail flow at all - in or out. I could login to the Admin GUI and all services were running correctly and no obvious errors being reported under the monitoring tab. Webmail was working - at least to view messages, and Files was working as normal, both via the web browser and the Nextcloud app for Mac OS. MacMail and my iPHone werre both able to connect to the Grommunio server as well.
In my setup I have a Xeams server (acts as an MTA, archive, spam filter etc) sat between my internet connection and the Grommunio server. Mail was coming in but not being delivered onwards to Grommunio server. Checking the SMTP conversations logs in Xeams reported that Grommunio was returning 'User not known on this server' error.
Since no changes had been made at all to the Xeams server this had to be something changed on the Grommunio server. As Xeasm passes all its email traffic to Grommunio, this was mosty likely something to do with the changes made under Section 23 of the upgrade recipe to the Postfix config files Main.cf and master.cf.
I swapped the 2 files for the one's I had backed up before the section 23 modifications were made. A reboot of the server and email started to flow between Xeams and Grommunio servers as per normal. I can only assume that Xeams is not happy with one or more of the changes to the Postfix configuration that were suggested. Once mail flow was re-established, Xeams made it easy to redeliver all the emails that had not been delivered to the recipients from the time I started upgrade, from its archive
Whilst my setup is not the same as many users who appear in this forum, I thought I would post this incase anyone else has similar issues.